Role of Gαq in smooth muscle cell proliferation

The role of autophagy in advanced glycation end product-induced proliferation and migration in rat vascular smooth muscle cells

Objective(s): To investigate the role of autophagy in advanced glycation end products (AGEs)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs).Materials and Methods: After culture, VSMCs were treated with 0, 1, 10, and 100 μg/ml concentrations of AGEs. Autophagy specific protein light chain 3 (LC3)-I/II was determined by western blotting, autophagosomes were observ...

Proliferation unleashed: the role of Skp2 in vascular smooth muscle cell proliferation.

Vascular smooth muscle cell proliferation plays a major role in the development of numerous vascular pathologies. Understanding the molecular mechanisms that regulate smooth muscle cell proliferation is therefore essential for the development of new therapies for the treatment of these pathologies. Skp2 is an F-box protein component of the SCFSkp2 ubiquitin-ligase that controls cellular prolife...

Paclitaxel and Arterial Smooth Muscle Cell Proliferation

1. Bentham J, Rodriguez-Arnao J, Ross RJM. Acquired growth hormone resistance in patients with hypercatabolism. Harm Res. 1993;40:87-91. 2. Ross RJM, Chew SL. Acquired growth hormone resistance. Eur J Endocrinol. 1995;132:655-660. 3. Anker SD, Chua TP, Swan JW, Ponikowski P, Harrington D, Kox WJ, Poole-Wilson PA, Coats AJS. Hormonal changes and catabolic/anabolic imbalance in chronic heart fail...

Hypoxic Pulmonary Vascular Smooth Muscle Cell Proliferation

Paclitaxel and arterial smooth muscle cell proliferation.

1. Bentham J, Rodriguez-Arnao J, Ross RJM. Acquired growth hormone resistance in patients with hypercatabolism. Harm Res. 1993;40:87-91. 2. Ross RJM, Chew SL. Acquired growth hormone resistance. Eur J Endocrinol. 1995;132:655-660. 3. Anker SD, Chua TP, Swan JW, Ponikowski P, Harrington D, Kox WJ, Poole-Wilson PA, Coats AJS. Hormonal changes and catabolic/anabolic imbalance in chronic heart fail...